Opioids may trigger worsening of pre-present central sleep apnoea (see area four.8). Concomitant use of oxycodone and sedative medicines which include benzodiazepines or associated medicines might bring about sedation, respiratory depression, coma and Loss of life. On account of these threats, concomitant prescribing Using these sedative medicines

Opioid-Tolerant Folks: In somebody bodily dependent on opioids, administration of a regular dose of antagonist will precipitate an acute withdrawal. The severity of your withdrawal syndrome created will depend upon the degree of physical dependence plus the dose of the antagonist administered. Even though the risk of addiction in almost any